Acute olanzapine toxicity in a toddler

Acute olanzapine overdose in a toddler: a case report.

We describe a 17-month-old female presented with an acute overdose of olanzapine, an atypical antipsychotic. She displayed prolonged extrapyramidal symptoms as compared with that in previous reports and prolactin levels above the upper limits of normal ranges. This is the first report to measure serum prolactin levels in an olanzapine-overdosed toddler and the second to calculate olanzapine's e...

The 'grey toddler'. Chloramphenicol toxicity.

A review of olanzapine-associated toxicity and fatality in overdose.

OBJECTIVE Given the increasing use of atypical antipsychotics in psychiatric populations and the very limited data concerning the safety of such drugs, we examined the available data on olanzapine in untreated overdose situations. METHODS Available toxicity data concerning olanzapine were obtained from the Offices of the Medical Examiners of Canada, the Canadian Adverse Drug Reaction Monitori...

Ibuprofen and acute renal failure in a toddler.

I buprofen and paracetamol are equally effective and widely used antipyretic agents in paediatric practice. There is no evidence to support the concept that treating a fever with antipyretics, paracetamol, or ibuprofen, will prevent febrile convulsions. Ibuprofen is available over the counter and is used in addition to or instead of paracetamol both in hospital and community settings. It is adv...

A case of imipramine induced toxicity with Brugada electrocardiographic pattern in a toddler

Tricyclic antidepressants (TCAs) include imipramine, desipramine, amitriptyline, nortriptyline, doxepin, trimipramine, protriptyline, and clomipramine 1) . Among these, imipramine was first synthesized in 1948. However, it was not until 1958 that its antidepressant affects in humans were recognized. Since then, it has been the prototype TCA. Imipramine is used for the treatment of non-bipolar d...